I use a keyboardio which is pretty similar to the moonlander layout and don't really have much issue with switching between it and my laptop keyboard. Ive been using it for a few years now, so I don't remember exactly, but I think in the beginning while I was still getting used to keyboardio I had trouble switching between them, but once I got better with it they were different enough that I can use either with no real issues. If I had to guess, in the beginning your brain is a little overwhelmed with the new keyboard layout that it gets a bit foggy when switching back to a regular one, but then once you learn the new layout it kinda solidifies in your mind and becomes a separate muscle memory.