Scientists found a cannabis compound that relieves pain without the high
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195 replies
Pass.
Call me when they develop weed without pain relief that only gets you high as giraffe balls.
Huh...I've always heard "giraffe pussy." Lol I never thought about it the other way.
It takes 2 giraffes.
I hate the pain relief/numbing aspect of some strains, it makes me get comfortable in positions that don't make me feel bad til the nexy day and then I feel bad for a week
Maybe you and I can go splits. You can have my share of the stone if I can have the pain relief part.
Call me when they develop weed that gives all the pain and none of the relief!
Let's spice things up, russian roulette with weed instead of bullets.
so they have these gummy bears with a shitton of capsaican, like 9,000,000 scovilles or something. you're supposed to chew them for 5 minutes, and they say it's like getting maced in the mouth. maybe a 6/10 of pain or something, it's intense but it's over fast. also you can make it easier with milk, that'd probably drop it down to a 4/10 or something. But 5 minutes and it's over.
if you want a pain russian roulette, use those.
Now that's the idea.
Ngl that just sounds like my normal weed for years. Originally took it for foot pain after work and it did nothing, but I was high as fuck and didn't care that much
that's kind of how it works though. The first time i took weed I was doing 12 hour shifts in kitchen work, and i noted how it didn't remove the pain, it just made me stop careing about it.
Smoke enough of the right kinds, and it will make your skin numb.
Definitely still couldn't walk properly because of pain, seems a bit pointless, but that's just me
TBF foot/leg pain to a 20 something, is not the same as chronic pain due to an injury, so i'm not discounting you, just voicing my experience.
also, i was smoking 'mersh not the medical grade stuff, so...
Call me when they invent weed that makes me feel like I'm wearing grade 7 nipple clamps
Yall are fuckin wierd lol. I absolutely love cannabis, both recreationally and medically. But if there's an additional choice to isolate the pain relief aspect without the psychoactive effects of THC, that would be amazing as well. It's not an either/or choice - there are absolutely use cases for both. Regardless, I'm pretty skeptical that terpenes are any more useful for pain control than essential oils are.
This industry relies on innuendo and bots to fill comments on Reddit, anything but actual clinical trials with placebo controls. Same thing with terpene sleep aids.
If I'm not wrong, essential oils are rich in terpenes and maybe that's what makes them useful as a pain treatment.
Essential oils are not useful as pain treatment.
I have friends that use them and disagree.
You have friends that have made a therapeutic ritual out of using essential oils which helps them only because the placebo effect can be very powerful for pain. Literally anything could stand in for the essential oils. Swap their oil vials out with convincing fakes and they'll never know the difference because it's the ritual of smelling and/or applying the oils that's helping them, not any real physical mechanism of the compounds in the oils interacting with their biology.
Thing is, this is the strain that's gonna be legalized if any. So any fun use would still be illegal.
The states in the US that have already legalized weed are not going to let go of that tax revenue anytime soon.
Sounds shit. Gimme both tx
Because you’re not allowed to feel good with any medical treatment.
No.
Or because plenty of people want medicine without unwanted side effects.
Yah the mental haze isn't a fun trap to fall into. (young me as source)
Maybe you want to drive a car safely.
Then I use paracetamol and codeine, and stay off medicinal cannabis
codeine is an opiate. you're not allowed to drive on that.
let me literally tell you what my pain management MD told me. "Practice doing the sobriety tests on opioids until you can pass" i think i had the worst doctor.
was his last name zuckerkorn?
i wish i was joking
In UK you can if it doesn't affect your driving.
and how do you tell if it has? imagine if the standard for alcohol was the same...
If you can drive safely then go ahead but if you're impaired by too much of anything that you would drive poorly then don't. I thought this was common sense.
the uk sticks out in the statistics of legal limits for alcohol in europe at 0.8‰ BAC; most countries are at 0.2 with some having a zero-tolerance policy, because it affects people so differently and it's hard to tell.
I am here
I take one tablet, if I need to
"Take opioids instead of non-psychoactive cannabinoids for pain" is a wild take my guy
I once had a social worker tell me I should stop smoking weed and get on opiates. I told him he could go fuck himself.
There was an injection of tongue in cheek with the first comment as well, but that seemed to have missed most
There’s a big difference between one Panadeine forte and the opioids you might be thinking of. Sometimes it’s just a paracetamol
...paracetamol is not an opioid.
i am sure this cannabis is safer than paracetamol or codeine. and there are people who want that
Codeine can still make people sleepy and sluggish. It's still an opioid that can lead to dependence and withdrawal. It still has negative GI side effects causing constipation. It's not a good idea for driving while under the influence. If this can help people in pain without side effect that can cause impairment, why not. Getting high off of cannabis can still be allowed.
the first time i took Hydrocodone was after I had my wisdom teeth pulled. I slept a full 8 hours, got up, took my next dose, and then proceeded to pass out for ANOTHER full 8 hours. I put two and two together pretty quickly and just decided to deal with the pain.
I’m not going to argue, really
I take one if I have to drive and I’m in pain.
You don't need to argue. You just need to accept that every time you do that you put your life, and the lives of the people around you, in danger. And that's simply a fact.
Yeah look I think there might be a difference between one Panadeine forte and hard core opiates that have people nodding off.
Certainly, it’s a lot better than vaping two caps before driving and nine times out of ten it’s just a paracetamol anyway
My friend, in the UK you can literally buy Panadol both with and without codiene over the counter at a pharmacy
They have said multiple times they use the without for the most part, which is just paracetamol (acetaminophen).
The UK and elsewhere don't have the same problem with opiates as the US does.
It's not an offense to drive on medications unless it impares you, in effect giving the police reason to stop you from driving if impaired by it and legal means to prosecute you if you cause harm due to the imparement.
That also means I could drive whilst high from my cannabis prescription if there was no imparement.
Its not that its no offense, you simply can't be prosecuted if no one knows about it. But that doesn't equal legal. If you get into an accident and anyone finds out that you took opioide, even just medical painkillers, you will be attributed most of the blame in court.
A prescription only provides defense in court, not an immunity to prosecution. It still is in your responsibility to prove that you weren't impaired by your medication, which is nearly impossible. If your tolerance is high enough that your reaction time doesn't decrease, then its nearly useless either way.
But if you have cannabis without the high, you could use that instead and be safer.
I’d love to have the option as a medical marijuana user. Not as punishment for having pain, but for having more options.
Yeah look, I don’t it’s a bad thing at all, I know this would benefit many people
Your parent comment resonated with me, I get that knee jerk reaction about punishing pain. But yeah I can begrudgingly admit that I would use this if it was available for driving and such.
Ok thats not exactly an improvement.
On one hand, it sounds like Puritanical bullshit, but on the other hand, I’d like the option.
Idk some people like going to work without pain.
For me cannabis is an incredibly strong depressant. I can feel suicidal for free with pain, thanks.
Hey, that's cool! This seems promising for enabling people dealing with chronic pain to have more options for ways to control pain without needing to potentially compromise mental function when they need it. Now to scroll through the comment section to see everyone's completely reasonable and measured takes.
Hey welcome to the internet friend, I hope you enjoy your first day!
https://en.wikipedia.org/wiki/Eternal_September
What do you think happened to cocaine and heroine? Hell, alcohol some places.
What happened to them? I really don't know the history behind these hard drugs.
They started as medicines and were concentrated, distilled, and extracted to the point where the medicine it became was deadlier than the cure it provided.
Coca leaves are still consumed medicinally/recreationally in some parts of south america.
Poppy seeds have a whole history of being abused and weaponized through the silk road.
Marijuana has faced a similar story, though without the deaths. This hasn't stopped governments around the world from conflating the deaths caused by other things with the use of medicines that in no way cause death.
I have to point out that in medicine we use the derivatives from cocaine, novacaine, lidocaine, benzocaine etc as potent short/medium term anaesthetics. Drugs like these make dental extractions for example relatively painless today. Pure cocaine was used previously but was far more toxic to the liver and had a much higher incidence of allergic reaction than its modern derivatives.
I miss my MJ, but it fucks with my heart so it’s a no go for me. It was critical to my recovery after a head on collision and the after effects. Doc was prescribing dilaudid, and that shit is something like sythentic heroin and his nurse i calling like every week to find out why i never filled the rx.
Nooo thanks. I hope this proves to be viable.
Weed smells like pine trees because they both have the chemical in this "study".
https://www.webmd.com/diet/what-to-know-pine-needle-tea
It's way easier and basically free if you have any sort of access to a pine tree.
Which is why no one pays for studies about that method.
who told you weed smells like pine? am i the only one who thinks that's crazy?
https://www.leafly.com/news/cannabis-101/what-is-pinene-and-what-are-the-benefits-of-this-cannabis-terpene
If you haven't noticed, there's a shit kind of different weeds.
That is mainly due to varying terepens.
Some weed, smells like pine tree to various degrees.
neat thanks
i read that as 'vaping preteens' and got confused for a sec
good info though
The children truly drive innovation
You know some people can’t smell pine?
I’d use it, if it were legal and wouldn’t threaten my job. I have no interest in getting high.
And then it gets patented and costs $10,000 a dose.
Currently happening with kratom and psylocibin as well.
Yeah, the most legit meds come from a gas station.
I don't think you know what you're talking about. There are multiple patents pending on modified kratom alkaloids.
https://en.wikipedia.org/wiki/Deuterated_mitragynine?wprov=sfla1
I've read about others but that was the first one I came across in development.
Psilocin pro-drugs are another category with multiple patents pending, Mindset Pharma holding a few.
https://en.wikipedia.org/wiki/MSP-1014?wprov=sfla1
Here is another patented by Reunion Neuroscience.
https://en.wikipedia.org/wiki/RE-109?wprov=sfla1
Because god forbid anyone ever feel a high that doesnt benefit corporate cartels.
I mean, i don't want to feel high while i try to relieve some pain yk
ITT: a lot of people who don’t suffer from chronic pain.
Has science gone too far?
This is so stupid. Just more pointless research to make you look the wrong way. Like Cannabis is this miracle plant that could offer us things we didn't have access to before.
I love Cannabis, she has been one of my best friends for over 25 years but let's not kid ourselves. These terpenes aren't unique to Cannabis, you shouldn't be getting them from Cannabis, you should be getting them from your food.
Unfortunately the food you are sold is dead and empty. Not only are processed foods stripped of all you actually need to support a healthy body, the fruits and veggies you buy are mostly dead strains that are grown in dead soil. It's cheaper upfront, but then you have to pay for it in supplements, taxes and hospital bills.
Geraniol: Citronella, rose, lemongrass
Linalool: Lavender, mints, citrus, coriander, basil
Beta-caryophyllene: Black pepper, rosemary, cloves, hops
Alpha-humulene: Sage, hops, ginseng, ginger, mints
Terpenes are the key. Spice up your lives.
Slam it to the left if you're havin' a good time, shake it to the right If ya know that you feel fine
Chicas to the front! Ha! Ha!
Man, I always thought that line was a reference to 90's sci fi show Space above and beyond....
But like, the buzz cures pain too. Or is no one else dealing with depression?
Depression isn't real, now back to rowing your oar, slave.
They made it suck.
They already did this a long time ago, with Marinol, a course of which costed like 20k, while a 50 dollar baggie of weed would better do the job.
Didn't that shit also have tons of side effects? I vaguely remember someone I knew took it and it made them nauseous
:(
Booooringg.
My dad his disautonomia so he has to smoke weed in order to cope with the pain from his nervous system.
He'd rather not use pain killers aka morphine aka opiates for risk of getting addicted to those.
Hopefully this compound will help his pain tolerance without giving him the high
Devil weed, everyone involved should be killed and the research burned.
That's why they are finding out about this now and not 1950. Witch hunts are so great, everyone benefits (not).
Gettingbhigh is very important to me, and I stand by my statement.
Publically. Bonfire style. In the middle of city square.
Instructions unclear, now someone's hosting an execution-themed costume party downtown while blasting Childish Gambino Bonfire mashups
I'm.... actually OK with this
Dunno. Sounds they were clear enough
without the high, double blind human trials will be relatively easy. looking forward to that.
Is it a noose made of hemp
Can I get the high without the pain relief? I don't like risking overdose on too many marijuanas
That's the second path of the production line.
Damn science! Ruining everything for everybody! /s
Not* sure how that's possible because the high is what relieves the pain for me. Not thinking about pain when I'm stoned off my ass.
We'd just have to try it and find out, I guess.
Surely couldn't hurt, especially if it doesn't affect your tolerance for THC. Cause I really need to take a tolerance break, but I need pain relief and sleep more.
What about CBD-based sleep aid gummies?
Unfortunately I've been there, done that. I feel nothing from CBD whatsoever. No pain relief, no appetite, no sleep. Feels like eating a snack
Nope, I need my THC, so it'll be interesting to see how this discovery plays out. Maybe I can finally get the relief I need without worrying about needing t-breaks.
Yeah unfortunately I'm the same way. Have tried several CBD things and not one of them do anything for me unless I go max dose, and even then it's an incredibly mild effect. THC takes nearly nothing though, 15mg is enough for a very strong high. I have friends where the complete opposite is true and I would love to trade them.
Having a low tolerance is great for your wallet!
Oh it absolutely is, and I've got a low tolerance for alcohol too, which is pretty nice. I just wish that if I had to choose which of THC and CBD I had a low tolerance for, it'd be CBD.
I'm not sure how you can objectively say the high is what gives pain relief. The two are intrinsically linked for you, and you'd be unable to know if it's one or two chemical processes happening in your body at the same time. It's just impossible to know.
Terepenes from weed are pretty much pseudo science, and the furthest this goes is "may be beneficial"...
Chocolate is also beneficial, "beneficial" is a very low bar. It doesn't mean the stuff in them doesn't work, it means it's a very inefficient way to get that stuff. Like drinking expensive wine instead of just eating some grapes.
If you actually want to try terepenes, you do what people across the planet have done for thousands of years and make pine tea. A single pine tree provides limitless fresh ingredients year round and you can get a much higher dose with zero other stuff.
Weeds cool and all, but it's always so stupid when people talk about the expensive chemical way and not the free and natural way.
technically all weed is just weed and really the only difference is the terpenes and maybe the THC versus CBD ratio. I used to think people who said the strains were different were ignorant and just experiencing a placebo effect until I smoked regularly and understood that the effects are indeed completely different and must be influenced by terpenes or other chemicals in the plant, cuz otherwise how are they so different?
Bruh, it's not just two, there's a shit ton of different kinds of both main types, and a few others.
That's why "delta 9" and the original "spice" shit started out close to real weed, they used the closest chemicals to the main ones. Then those also got outlawed and they used worse ones, to now where I'd assume it's just bathsalts and kratom.
That's the maine difference.
Unless you're smoking insane amounts of flower, like Willie Nelson levels, terepens are just flavor. And by that point you're too stoned to notice.
Circling back to other methods of terepen consumption.
This is being pushed because it can be stripped from hemp when they make delta 9 shit.
As I've said a pine tree is all the terepen a community could ever need.
Im saying thc and cbd likely have the most profound effect. I said there were other chemicals. Also delta 9 is regular thc no? delta 8 and delta 10 and HHC and THCa and all that are the "legal" derivatives that aren't spice.
Yes...
That's what I'm saying. It's not a binary ratio. Even with the same percentage of THC or CBD, that is many different types of THC and many different types of CBD.
And then there are others, which similarly have a lot of variations.
It's only complicated if you still have simplified Mendelian view of variation. Real life ain't 6th grade science man, shits fucking complicated.
The same plant will have variation on itself, even clones have variation.
Boo
Well where's there fun in that!?
Your comment may be read as serious or jocose, and both work.
My serious thought is that if I'm fucked, I might as well use any means at my disposal to lessen my suffering.
I thought we knew how to do that for decades already
Lol. Where's the fun then haha? /s
Could be a motive to disallow the sale of cannabis seeds.
Illegal... and highly dangerous for reasons in 3, 2, 1
Reduces pain in mouse models?
It's a nice way of saying:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8621025/
Explains it more in depth:
Classify that shit
I'm sure it has it's uses, not for me lol
Don't we literally already have this? Medically prescribed cannabis is pretty weak sauce already I wasn't aware that this required further research really it's just a breeding problem.
Of course they did, god forbid anyone should have any fun. Fucking puritans.
Ok, but now imagine being in chronic pain and wanting relief without getting high?
That'll be $10,000
Pharma company extracting novel compounds to sell? Ya look at the insulin fiasco?
I mean, sure, but that wasn't what they were flippant about
Yes, but the thing they were bring flippant about is exactly the niche that'll be excessively monitized.
Fuck that.
What sort of goof ball wants to take cannabis but doesn't want to get high?. You could choose from several other pain killers that already do that. Theres no need to ruin perfectly good weed.
Someone who uses cannabis medicinally and wants to have the pain relief without the high sometimes.
If you don’t understand the difference in pain relief from weed vs opioids you wouldn’t understand why some would appreciate weed strength pain relief without the high.
Or, and hear me out, NO.
Why?
Umm, because I want the high.
So people who don't want it don't deserve to have that choice? This makes no sense
I think they mean that, as long as it doesn't exist, they can use the kind that does both, but as soon as it does, their boss will insist they use the boring kind.
How about just taking the choice away from their boss?
First time dealing with late stage capitalism?
Whom precisely do you think wants that decision in their bosses hands?
So you want to medically hurt others ability to function just because boss might find out? Lol
then toke it up.
some people still want to function without the pain.
Yeah, but what's your point?
I love as this news spread, all the "but i need it for my pain/depression/etc/etc!, its the only thing that helps!" types are now just straight up basically saying they don't give a fuck about anything it does but the high.
I knew this was gonna happen.
Just like I know the type of responses I'm gonna get from the outed potheads and addicts.
Potheads and addicts? Holy shit, is it still 1990 and you’ve got some weird fucking prejudice against how other people choose to spend their time or how they medicate themselves? Oh boy…
You invite the circus when you put the clown mask on.
I dont care what you do in your own home.
But potheads, like vegans, cant just contain it to their own home and shut up about it. They gotta make sure everyone, everywhere, in every fucking conversation, knows about what they do.
And for the longest time, they all tried to hide behind pot being the magical medicine that cured all woes, and now we have science actually isolating beneficial components without hte high, and the overwhelming response is "NO, I DONT WANT THE BENEFICIAL EFFECTS, I WANT THE HIGH", which is exactly what addicts would say.
What kind of naïve person makes grandiose claims of others, while also unfairly aggregating them to the grouping of your own subjective, unflattering, and inaccurate images of them? You’re basically inventing these people, potheads and vegan, to make a dumb point about how some people like to talk about their personal choices a lot. Whoopty doo, you dweeb.
You know what’s funny? Aside from the fact that I’m mentioning it now, I consume a grotesque volume of cannabis. Truly grotesque, I promise more than whatever you’re thinking. I don’t bring it up, though, ever. Why? Because I’m an actual human being, as opposed to whatever fantasy you’ve got going on up there.
No it’s not. Please, for the love of god, do good research and get that stuff. That’s great for children, people who don’t want to be high, and people who can’t be high (e.g., on the clock) but still need the medicine.
I still want to get high, though. There’s nothing wrong with that. The issue is with you, if you have a problem with that.
sure buddy.
Well, at least your username checks out...
Sure buddy.
Wow....
You are the one who brought up vegens in a conversation about pot. But sure, keep telling that yourself.
Sure buddy.
You are shadowboxing lol. I see orders of magnitude more people complaining about vegans with little to no prompting than I see any vegans saying they are vegan.
Never met someone smoking weed who acts like a militant vegan about it.
I bet you're a riot at parties, huh.
If you're going to go for the personal attack, could you at least be entertaining with it? This is something a 14 year old would regurgitate 30 years ago.
Oh sorry, I thought I'd try for something a moron would understand. I didn't want to use too many big words and confuse you.
Next time try lowering the bar to something a moron can actually produce instead of worrying about other people 👍
So you want me to reduce my not-so-complex insult to something a moron would produce so you can think you're winning an arguing with a moron?
Fuck, you're smart hey.
lmao vegans and pot heads, oh no! ur a funny one
A lot of these comments are jokes, and poke at our for profit healthcare in the states.
vegans AND potheads, oh man, best joke in here is yours tho
There is zero evidence for a physiological dependency on weed. Stop making shit up.
Yeah... Maybe they like getting high too. What's the problem? The only issue I see with cannabis is that people smoke it.
There are tons of issues with cannabis. It severely diminishes your ability to solve problems or concentrate on complex tasks over a period of time. I'm not in favor of people casually being drunk every day, and therefore I am not in favor of people casually smoking weed every day.
If we want people to be able to get the medical benefits of cannabinoids, like anti-emetics, pain relief, appetite, anti-psychotics et.c. we need to research their mechanism of action and synergy between each other. People who are sick do not necessarily also want to be high, especially if you have to take your medication over an extended period of time.
So cannabis and alcohol bad, caffeine fine?
Caffeine and nicotine are problematic for various reasons, but they are not significantly mind-altering. Because of that, chronic use of caffeine and nicotine is not problematic with regard to being able to perform most tasks.
Oh wait, you're serious.
Are you implying that it's dangerous to drive or inadvisable to do your taxes after drinking coffee?
Rage bait.
Used one without the high. Worked beautifully. Too expensive in the long run. But really appreciated it. Dont want the high at all. It had no side effects. Just gentle pain relief. Bliss.
@Timonesaysno I love the high from cannabis, but that doesn’t mean that I want it necessarily in all situations. Like for instance, on Friday night I randomly got nauseous, and the only thing I had was my THC vape. Well, I didn’t care, because we were having fun anyway, I may not have been able to get away with that is easily outside of a chill situation, such as a softball game, which is where I was last night.
If I'm in chronic pain then I'm going to want to be high too. Nothing wrong with being high in your own house.
-I don't even like weed. The high just feels like taking benedryl to me.
It would be better to have both as an option.