Cross posted from: https://europe.pub/post/13201474

Check out the amazing Conclusion from the primary source: "Daraxonrasib was associated with treatment-related adverse events of grade 3 or higher in one third of patients with previously treated RAS-mutated PDAC; antitumor activity was also reported." 😑

Fucken market manipulators, smdh. Just let Black-Scholes-Merton function naturally.

I love cooking and botany,

But I don't raise no dang chia,

So much pesto on my psyche,

Call it a basil ganglia.

Cross posted from: https://futurology.today/post/10589625

Sign language

tl;dr: Pre-colonoscopy bowel prep really took a lot outta me: crazy shit.

Hi Lemmy. I was gonna message my small friend group to wish me luck (aka retroactive positive causes) for my colonoscopy that's happening in 45 minutes. But I realized I'm not really that close to them. I always end up oversharing and while that can build emotional intimacy in some friend groups, it unfortunately hasn't with this group. And I dont have any other friends or family to speak of.

I'm kinda scared tbh. Not about the camera in my GI tract part, I'll be on Milk of Amnesia for that part. It's more because I got an abnormal result on my preliminary Cologard test, and while I know it has a high false positive rating I still can't shake it. My background's in healthcare so I knew enough to not postpone this merely because it's unappealing. I always prefer knowledge over ignorance.

It's just that so many people have passed away from gastrointestinal cancers: Chadwick Boseman, James van deer Beek, Audrey Hepburn, Pelé, Kirstie Alley, Charles M. Schulz, Milton Berle, Jack Lemmon, etc. The category of strangers I tend to interact with on Lemmy are the people I feel closest with in a way, which is simultaneously reassuring that I have that but also feels pathetic. Like I should be bullying myself.

Anywhoozles, I'll at least be happy to end this 36 hour damn fast soon enough with natural and healthy air fried chicken tendies and a pint of Ben & Jerry's chocolate & peanut butter ice cream. I'll eat actually healthier (and something with fiber) after I smeep.

Apparently the rate at which I'll have to repeat this (assuming good news) is dependent on whether the Doc had to burn polyps, etc while spelunking in there. It can ramge between 1-10 years depending how well it goes. Worst case scenario when GI cancers are caught early they're among the easier to treat. I believe people even keep their hair so I can do that.

Life's pretty crazy the older I get, and the longer I live the crazier I get. While I'm mostly content, I sometimes wish I could find someone as crazy as me to share my life with. Until then, I can find outlets in writing this brief diarrhy entries where if no one reads it it can always serve as a time capsule for old me. Hi me, it's you: me. How've you been? I wish I'd appreciated the years better.

Love, qualia

Edit: Ollie ollie oxenfree: no Big C for me this time. They burned a few bad guys off and I have to do another one in three years. Thanks for all tbd strong empathy from this community. I literally posted that like ten ninutes before they wheeled me into the OR. Wish I could've read these before it went down. Thanks again.

methylpheniDate

“It’s where I met my wife Rita Lin”

Edit: This is a genuinely interesting story, y’all downvoters are just wrong. 🤭

Anti-gray hair topical via melanogenesis rescue: proteoglycan mix restored melanogenesis-associated transcription factor expression 3.7x in human melanocytes, with 4x synergistic antioxidant effect.

The latter is interesting because while H₂O₂ is a normal byproduct of cellular metabolism, its metabolism by catalase expression drops significantly with age. This means the accumulated H₂O₂ (a ROS) literally bleaches the melanin from inside the follicle using the same mechanism that cosmetic bleaching products lighten hair.

Problems with this study:

• In vitro only
• Manufacturer-funded
• Arbitrarily women-labeled despite gender agnostic study
• Cosmetic-classified to dodge RCT standards and market to anti-pharma segment

https://pmc.ncbi.nlm.nih.gov/articles/PMC12846973/

Next step: cross-platform marriage

Next step: cross-platform marriage

It's also totally possible they just have zero self-awareness.

You can’t prove my convictions are unfounded if I keep getting lucky.

I use a saddle stitch.

That reminds me: why aren't we saddling our children with an education in ethics or any philosophy prior to university? It would've made me a better person much earlier for one. Is it because of the tension between the simultaneous importance of the separation of church & state and the fact that many people's morality derives from religion? So that even teaching the same lessons with the parables removed would potentially be considered culturally threatening? It's simultaneously very important and a fight not worth tackling right now somehow.

Evidence of unsafe medical practices

According to footage recorded over 32 hours inside the hospital, healthcare workers were seen using the same syringes on multiple patients, drawing medication from multi-dose vials and then administering them to different children—practices experts say create a high risk of viral transmission.

TIL that all some UNIX based systems have a Y2K38 superbug in which the number of seconds that have elapsed since the Unix epoch began (Jan 1, 1970) are stored as a signed 32-bit integer which maxes out on March 14, 2038.

I suppose Proton Calendar is just using a generically premature cutoff because reasons. Unfortunately experts report no known solution to this problem and we will very likely be without computers after this date.

Edit: The recent discovery of signed 64-bit integers (as published in PNAS) will now allow us to kick the can down the street an additional 292 billion years until overflow. Unfortunately, this only delays this apocalyptic problem for a mere 21 times the age of the universe.

I'm not as familiar with CommonMark vs Markdown, but haven't been able to get a tilda character to display in the app. I verified it was successfully passed into the raw data, yet despite trying several typical escape techniques to preserve it (backslash, backticks) or its html entity reference (~) it either gets removed or not translated.

If this isn't an app issue I'd very much appreciate some debug advice for my brain.

This excellent Jon Glaser-created Adult Swim comedy horror series is fully watchable on DailyMotion. Get hooked in by the Paul Rudd, stay for the deadpanly-manic comedy (Glaser wrote & performed on early Conan).

Oh, hey I forgot to tell you it also features 30 Rock and Mr Show alum Scott Adsit.

The icon of this community combines the rod of asclepius (symbol for modern healthcare¹) and the scales of justice (symbol for law). But unjust laws exist so the scales of justice aren't sufficient to describe the ethics in bioethics. However, all just laws are necessarily a subset of some ethics.

It's an open philosophical question how to relate ethics and law. There's Rawlsian, utilitarian, and retributional justice which aren't commensurable among one another. WH von Wright's normative logic includes operators of obligation and norms to try to formalize the problem.

As an informal bioethics platform I reckon one of our core values should be steelmanning one another's arguments. Since we don't know which ethics subsumes the largest set of just laws, it will always be valuable to give benefits of the doubt².

1: I consider healthcare to be appropriate enough for the bio component of bioethics since it's similarly the desirable condition of life.

2: For example did I just awkwardly modify an idiom? Much so.