Oh boy it's my time to shine!

I'm working in aging right now. Heard of Dr. David Sinclair since he was the corresponding author on a paper I was curious about... So this is what his lab is doing.

Two important disclaimers:

• Success in cellular research rarely translates to something viable in the clinic. A lot of chemicals don't behave the same way in cells as in actual animals or humans. Heck, a good number of phase 2 drugs even fail, and these haven't even made it into phase 1... so I wouldn't be too optimistic about them.
• The journal Aging is not the most prestigious journal especially for someone working at Harvard Medical School (HMS) to be honest. I'd be more excited if this was published in Nature Aging or Nature Communications or something. If this ever gets published in New England Journal of Medicine (a very prestigious journal only for clinical studies) then we have some news.

The link between cell senescence and aging is something actively being studied tho.

And, if anyone is curious about this topic: I'm also very actively following Dr. Vadim Gladyshev who is also from HMS and is working in aging, I believe he is doing some wet lab-biology on a similar area as well. Feels like his research is sometimes a bit ahead of his time but I think his work has great potential.

ELI5 about the Chinese real estate market in general? This is how they got to where they are today:

• Investing in China sucks. The stock market is extremely volatile and there seem to be a lot of shady activities, banks get bank runs so you couldn't even put too much money in banks, etc
• In contrast, real estate is heavily subsidized by China's state capitalistic approach, so it became a really "stable" investment... because government subsidized it
• Because of this, everyone buys or want to buy real estate in China. In fact, people are willing to buy places that would almost never be lived in, because of possibility of appreciation... so we're approaching NFT-level bullshit here
• Additional point: because of the above point, Chinese investors would buy real estate even when abroad & the RE market is not nearly as favorable. Obviously this causes some frictions... like a good chunk of Canadian citizen blaming Chinese ppl on raising home prices
• Chinese economy is now facing hardship, so the real estate bubble is finally showing signs of leakage in the past few years

I am not an economist and cannot offer insight as to whether this would turn into an 2008 moment... Nevertheless, I am aware that Soho is an extremely well-known developer, and that the Chinese economy is to a large extent built on top of real estate. And despite how much I dislike China, it is one of the world's largest economies, and large economies don't just go belly-up without inflicting heavy damage on the whole world... So this is not good news by any means.

So having all the mods quit is actually a viable way to protest? (writes down notes)

Second this!

Phones give out a lot of personal information on their own lol. On top of the phone, don't forget that social media apps like Threads also require you to login... with credentials stored at FB/Meta... that they can derive all the aforementioned information on, as well as other type of things (Amazon purchases? Stuff you watch on youtube.com? Google queries?...) by using some creative tracking technology. You basically gave them a dog tag to identify you whenever you sign up for services after all

For shittier apps like Thread, apparently they also do some weird stuff like forcing the app to be on once the OS boots, so... yeah.

Out of curiosity... Anyone use the Steam Deck as a computer beyond just gaming? I don't play games that much but I'd love a decent spec portable computer that I can also use to play video games, the price is quite generous given what its specs look like so...

... wait am I the only one who conscientiously not want to upvote my own posts because of that?

I'm sorry OP I couldn't answer your questions directly since I am in a same boat, so I can only share my experience trying to get there... Maybe some of this would be useful

Where did you decide to move to, and what were the things you looked at when deciding to move there?

So the only immigration-friendly countries I can find are Canada, Australia, and Germany. Not a big list to begin with, but for US citizens there might be more options with other EU countries. Canada has... issues, someone else in the thread mentioned about their experiences. Australia apparently is closing its doors. Sweden used to be fine but I heard things went really South for them a few months ago.

And if you're a lurker on Reddit you probably know r/IWantOut? Country-specific wise I know r/Germany has a phenomenal wiki for their stuff, and Canada has r/immigrationcanada. Unfortunately a lot of good information is still on Reddit so yeah

Other countries... I don't think Asian countries do much immigration at all, feel free to correct me if I'm wrong. Maybe some EU countries are fine depending on heritage and/or where you are from. I have no idea what's going on in Africa, if anyone knows something plz let me know.

Where can I start? How can I realistically make it happen?

For your privacy plz don't answer in this thread, but 1) how old are you, 2) what type of education do you have, and 3) what type of work do you do? Having a college education and an in-demand career goes a long way, although this is also country-dependent. And yeah under many circumstances your employer could help you with the process. Certain parts of Canada and Germany obviously have language requirements, but a lot of other countries accept English. I heard some places allow investment-based immigration, but 1) it's expensive AF and 2) not sure if countries that allow this plan are remotely desirable for US citizens...

Also side note: please DO NOT give up US citizenship unless you have a really good reason to / already have something in your bag. I'm not a citizen here, and most US citizens have no idea how excruciating it is to immigrate to this country

I stand my opinion on this... Some people are defederating Meta because they are anti-capitalist; these are the same admins who defederated mastodon.cloud as well as instances from Medium/Mozilla/etc on moment's notice, so I think they will certainly defederate from Tumblr. Most people would probably want to at least wait & see since Tumblr isn't as nefarious as Meta is

Opinion you said?... https://manjarno.snorlax.sh/

Thankfully the Manjaro team didn't seem to have a major mess-up recently, but they did have some very troubled past. Especially now that Arch has a real installer that bundles entire DEs for you, the premise of using an "Arch Linux but easy to use" OS seems less and less

To each their own though! Nothing wrong with using Manjaro at all if someone really likes it

Thanks! Wowzers I've never heard of Nature Food, didn't realize this journal had such a high impact factor. A few things of interest to me from the article...

• Vegans are one standard deviation younger than heavy-meat-eaters and eat fewer calories... although they should have adjusted for the difference
• This didn't show on the fancy Monte Carlo simulation they did, but vegans emit much, MUCH less methane than any other group
• Literally any group is significantly better than heavy meat-eaters, especially low meat-eaters or below

The questionnaire they used to determine categories:

• Do you eat any meat (including bacon, ham, poultry, game, meat pies, sausages)? (Vegans, vegetarians and fish-eaters respond ‘No’.)
• Do you eat any fish? (Vegans and vegetarians respond ‘No’.)
• Do you eat any eggs (including eggs in cakes or other baked goods)? (Vegans respond ‘No’.)
• Do you eat any dairy products (including milk, cheese, butter, yoghurt)? (Vegans respond ‘No’.)
  And meat-eaters are divided by grams of meat eaten per day: <50 g/d, 50-100 g/d, >100 g/d. Apparently one patty from McDonald's (Big Mac has two) is like 45 grams of beef so...

I mean the conclusions aren't anything surprising, cows are literally one of the major sources of environmental damage... But it does provide some way moving forward I suppose. I suspect banning steakhouses would have a much better impact than forcing everyone to be vegan lol

Oh god don't even mention it... I was already afraid it would break down last year (when we didn't have this extreme heat). I'm planning to leave Texas as early as possibly can partly because of all this craziness, meanwhile some of my coworkers don't even notice what kinds of nightmarish scenario is happening down here

Excellent read. Have just re-posted this on 'key, thanks for sharing this.
I agree that Meta is doing something very dangerous to the fediverse... hope they could be stopped in their tracks.

• "Are we involved in that, as are we a subset of lemmyworld?"
  No, since kbin.social and lemmy.world are not only two separate instances, but two different Fediverse applications (kbin / lemmy)... so yeah we're fine for now.

• "but any content I engage with is effectively visible"
  I self-host a small Calckey instance and previously self-hosted a Mastodon instance, and something I noticed is that different instances don't always federate well... So remote messages won't always show up.
  E.g. say I follow Eugen from mastodon.social so I see his posts. For example there are four replies: one from a guy I follow on infosec.exchange, one from a fresh new account on mstdn.social, one from a tiny one-person instance, and one from a suspicious instance that was quickly suspended. I can (most likely) only see the first reply from my instance because the latter three won't federate with my instance... so yeah that's completely normal.

• "How does this affect us?"
  As background knowledge: (some) people are awful. In practice this means that any large, open-registration social media WILL attract difficult people. To solve this, select at least one: 1) close open registration, 2) limit the size of the instance, or 3) be ready to put a lot, a LOT more effort into moderation.
  Many for-profit social media, as well as some large Mastodon instances, have to stay open-registration for various reasons, so they have to find large numbers of moderators to do the thankless jobs of filtering out terrible stuff. This doesn't always work smoothly. Pretty sure lemmy.world and sh.itjust.works were defederated because of this reason: open registration, and mods couldn't handle the bad people.
  Pretty sure kbin.social is still open-registration at the moment? I mean kbin isn't as popular as the previous two so I assume we are safe now, but unfortunately ernest will have to make the tough decision one day. Jerry from fedia.io probably already knows what to do since he already manages infosec.exchange, one of the larger Mastodon instances lol.

mailbox.org and skiff are „too expensive“ with 3€/month.

Ah... I do use mailbox.org and I've self-hosted with docker-mailserver before.

I agree, selfhosting mail is a really big pain, and at least where I live most ISPs don't open the ports necessary for mailservers, so I had to spin up my own server & it was more expensive than just using a mail provider. Could potentially be the cheapest option if I could host it from home & just use a RasPi or something

I'm happy with mailbox.org; the Standard Tier price is 2.50 Euro/mo if paid in full if that helps. Probably not the cheapest option especially since it's not unlimited, but they do allow domain matches at Standard tier or above, and there are other goodies like calendar/video conferencing/cloud storage & stuff.

Tried it myself with hardened Firefox, can confirm that's the case. It's even worse, my first search is "getting run over"...

Probably says more about the type of ppl frequenting YouTube than YT doing some shady stuff. Which honestly sounds more dystopian to me

P.S. Just realized youtube.com blocks Tor Browser, not cool Ytb.

Well the Steam Deck's OS is forked from Arch so.

I play mostly Indie so I couldn't speak for stuff like anti-cheat/graphics but... the types of game I play, for the most part "it just works".
If you're into RPG maker games, they sometimes require workarounds (hint: you can hot-swap the contents of RPG Maker MV/MX/MZ into Linux's native nwjs...)
I think the only games that struggle on my computer are mostly because of GPU (I'm on a laptop) rather than anything else Tbh

Ohhh so that's why... So the rice actually does do something? But I think the marketer who designed this needs to be sent back to high school to retake biology or sth

Yes and yes! Couldn't contribute that much but I try to

I think having a highly important FOSS project that is not controlled by a company known for shutting down many of its beloved products (I'm talking about you Google) is pretty nice...

Also I think map quality is location-dependent. I live in a large metropolitan area in Southern US; OSM is usable, but there are no house/building numbers, and a good number of businesses are missing. In contrast I think the map is a lot better in Chicago which is a lot more pedestrian-friendly? Also, when I looked at Germany it seems OSM is on-par or better than Google Maps... in fact one of the larger rental websites use OSM instead of Google Maps (imagine Zillow doing it in US lol)

For god's sake temperatures above 40 Celsius are dangerous and claims like this will literally kill some people... But again, after everything happening in the last 3-4 years it's hard to imagine conservatives putting other folks' health and safety as a priority

And as a PSA: YouTube might or might not be secretly cracking down on 3rd party clients. There have been issues with Invidious & yt-dlp and I have had a few instances where NewPipe on Android bugged out. Let's see where this leads to