Is the healthiest blood pressure one your doctor calls "hypertension"? - Dr Paul Mason
Studies of thousands of elderly patients have found the blood pressure associated with the longest life is about 129-130, a number many guidelines classify as stage 1 hypertension.
Paul and Alison work through your comments from episode 1 and on Pauls' nutrition masterclass delivered to doctors.
::: spoiler Summary
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Introduction
- The Dr. Paul Mason Show, episode two.
- Hosts: Allison and Dr. Paul Mason.
- Headphones are worn to improve audio quality after feedback on the pilot episode.
- Allison explains she is helping Paul share information after 25 years of friendship.
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Nutrition Masterclass for Doctors
- Paul gave an online tutorial to sports and exercise medicine trainees.
- The session lasted two hours.
- It focused on distilling science and addressing falsehoods in mainstream medical education.
- The goal was to help doctors provide evidence-based care.
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Comment on Apples and Potatoes Diet
- A viewer suggested eating only apples and potatoes would produce the same results as low-carb diets if weight is lost.
- Paul disagrees.
- Complex carbohydrates are chains of glucose molecules.
- Potatoes contain starch, which is a complex carbohydrate.
- Apples contain fructose, which Paul calls more deleterious.
- Digestion releases glucose into the bloodstream, raising blood sugar and insulin.
- High glucose and insulin drive production of palmitic acid, a saturated fat in blood.
- Glycemic instability affects brain function and weight gain.
- Low-carb diets stabilize blood sugar and reduce hunger.
- Ad libitum trials show spontaneous calorie intake drops when sugar and insulin are controlled.
- Apples and potatoes do not address satiety.
- Vegan and vegetarian diets lack substantive nutrition.
- Missing nutrients include B12, heme iron, retinol, K2, omega-3 fatty acids, and complete proteins rich in leucine and methionine.
- Short-term metabolic improvements may occur from calorie restriction, but long-term nutrient deficiencies will cause harm.
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Vitamin B12
- B12 absorption requires an acidic stomach environment and intrinsic factor.
- Absorption occurs in the ileum.
- Pernicious anemia is a failure of B12 absorption.
- Before injectable B12, pernicious anemia was universally fatal.
- Animal foods are the only source of B12.
- Paul questions how a diet requiring supplements to avoid death can be called the most healthful.
- Reference ranges for B12 are often 95% confidence intervals based on the general population, not optimal levels.
- One laboratory considers 135 to 650 adequate, but literature suggests levels below 400 are suspicious.
- The elderly are at higher risk due to reduced stomach acid and proton pump inhibitor use.
- B12 deficiency is linked to dementia, anemia, and impaired neurotransmitter synthesis.
- Some patients diagnosed with dementia no longer met criteria after B12 supplementation.
- Low B12 can cause depression and high cholesterol through molecular mechanisms.
- Paul recommends annual B12 testing at minimum.
- Supplements often do not require stomach acid for absorption.
- Intrinsic factor deficiency may require injections.
- Methylated B12 is preferred.
- Hydroxocobalamin injections are acceptable.
- Cyanocobalamin is considered less optimal.
- Carnivore dieters often have B12 levels of 800 to 1000, which Paul says is healthy.
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Weight Loss and Blood Pressure Medication
- A viewer reported losing 35 lbs, stopping blood pressure medication, and ending indigestion and sciatica.
- Paul quotes JH from 1931: "The greatest danger to a man with high blood pressure lies in its discovery because then some fool is certain to try and reduce it."
- The caveat is that 1931 treatments included bromides and mercury.
- Modern blood pressure targets encourage prescribing anti-hypertensives.
- A 2018 British Medical Journal prospective cohort study examined over 4,500 elderly Chinese people with a mean age of 92, including 825 centenarians.
- The optimal systolic blood pressure was about 129 mmHg.
- Lower and higher pressures increased risk.
- Diastolic blood pressure was nearly meaningless as a risk factor for all-cause mortality in that study.
- A UK study of females over 80 found lowest death risk with blood pressure between 120 and 139.
- A Korean study of over 68,000 adults found optimal range between 130 and 139.
- The American Heart Association would classify 129 as just below stage 1 hypertension.
- Paul views 130 as fine and desirable for most people.
- Very low systolic pressure increases death risk.
- In the last three months of life, blood pressure under 120 is common; under 110 carries the highest risk.
- The theory that lifelong elevated blood pressure is harmful lacks convincing data.
- Evidence for blood pressure medication improving mortality in younger people is weak, even up to 160 mmHg.
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Deprescribing
- A viewer commented that doctors are not interested in deprescribing.
- Paul says deprescribing is hard and not taught in mainstream medical education.
- Example: a diabetic on insulin who starts low-carb must have insulin reduced to avoid hypoglycemia.
- Blood pressure medication must be reduced as blood pressure improves to avoid dizziness and falls.
- Low blood pressure is more dangerous in the short term than moderately high blood pressure.
- Doctors receive guidelines on starting drugs but not on stopping them.
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Proton Pump Inhibitors
- PPIs reduce stomach acid and impair B12 absorption.
- Rebound acid hypersecretion occurs after stopping PPIs.
- The body upregulates acid production to compensate for PPI suppression.
- Stopping PPIs suddenly causes acid secretion to spike.
- 40% of healthy adults develop reflux symptoms after abrupt PPI cessation.
- Doctors often misinterpret withdrawal as persistent disease and restart the drug.
- Paul was taught PPIs were safe for indefinite use, but guidelines recommend short-term use.
- Long-term PPI use is linked to dementia, osteoporosis, and pneumonia.
- Deprescribing requires gradual tapering to reset acid secretion.
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Antidepressants and Deprescribing
- Antidepressants are technically not addictive because tolerance does not require escalating doses.
- Many patients experience withdrawal and cannot stop.
- Dr. Mark Horowitz developed the Maudsley deprescribing protocol.
- Antidepressant receptor occupancy follows a logarithmic curve.
- Small doses at the end do disproportionate work.
- Tapering should follow a logarithmic reduction, not a fixed percentage.
- Tablets often do not come in small enough doses.
- Compounding pharmacists can provide liquid formulations.
- The process can take 12 months or longer.
- Paul does not prescribe antidepressants.
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Informed Consent and Eminence-Based Medicine
- A dentist commented that patients ignore lifestyle advice because other doctors contradict it.
- Paul calls this eminence-based medicine, defined in a 1999 British Medical Journal article.
- Medical decisions are justified by the seniority of the advisor rather than evidence.
- Patients should ask doctors for the evidence behind recommendations.
- Informed consent requires full and accurate information on risks and benefits.
- Doctors often confuse absolute risk reduction with relative risk reduction.
- Example: a risk dropping from 0.1% to 0.05% is a 50% relative reduction but only 0.05% absolute reduction.
- Patients should ask for the actual paper or data, not just guidelines.
- Number needed to treat and realistic benefits should be disclosed.
- Some treatments, such as certain peptides, rely on preclinical animal or cell-culture research.
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Biofilms and H. pylori
- A viewer compared microbial biofilms eating holes in stainless steel pipes to human abscesses.
- Paul agrees.
- Abscesses are acidic and have poor blood supply.
- Antibiotics and local anesthetics often fail in abscesses due to acidity.
- H. pylori was discovered by Barry Marshall and Robin Warren, who won the 2005 Nobel Prize.
- Marshall infected himself, developed ulcers, and cured them with antibiotics.
- Standard H. pylori therapy combines two antibiotics and a PPI, with a 70% to 80% success rate.
- H. pylori may live inside Candida albicans, which shields it from immune cells and drugs.
- Biofilm disruptors such as vitamin C and certain probiotics may improve treatment success.
- Paul tests patients with reflux, bad breath, or epigastric tenderness.
- Tests include urea breath test, fecal test, blood test, or biopsy.
- Urea breath test results can be nuanced; borderline readings may indicate low-level H. pylori or other urease-producing microbes.
- Second-line treatments include bismuth and fluoroquinolones, which have toxicities.
- Antifungals such as amphotericin B lozenges or nystatin may help in resistant cases.
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LDL Cholesterol Causes
- A viewer asked what else raises LDL besides underactive thyroid.
- Paul treats high cholesterol as a symptom with root causes.
- B12, folate, betaine, and choline are methyl donors.
- Undermethylation of genes regulating cholesterol production raises cholesterol.
- Underactive thyroid is associated with undermethylation.
- H. pylori can cause nutrient malabsorption and low B12.
- LDL is part of the innate immune response and binds bacterial toxins.
- Chronic infection is the most overlooked contributor to elevated LDL.
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Water, Electrolytes, and Heart Palpitations
- A 57-year-old viewer reported drinking 2 liters of water daily and having nighttime heart palpitations after starting carnivore.
- Paul advises seeing a doctor for cardiac symptoms.
- Drinking plain water can deplete electrolytes.
- Low-carb and carnivore diets lower insulin, causing kidneys to excrete more sodium.
- Reduced sodium lowers blood volume, which can reduce stroke volume and raise heart rate.
- This is called keto flu or Atkins flu.
- Paul recommends supplementing electrolytes, including sodium, when starting strict low-carb diets.
- Magnesium loss can contribute to palpitations and arrhythmias.
- Most magnesium is inside cells, so blood levels may not reflect total body status.
- Beverage hydration index: adding electrolytes increases fluid retention.
- Commercial electrolyte supplements often lack phosphate, calcium, and individualized ratios.
- Iodized salt is good for iodine intake.
- Paul prefers mined salt over sea salt due to concerns about microplastics and impurities.
- Excessive iodine can cause the Wolff-Chaikoff effect and hypothyroidism.
- Too much sodium increases urinary calcium loss.
- Paul uses reverse osmosis filtered water to reduce microplastics, forever chemicals, and fluoride.
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Diet While Traveling
- A viewer found it challenging to maintain diet during a month in Japan and gave up.
- Paul says do not let perfect be the enemy of good.
- He uses a hierarchy: some foods are non-negotiable, others are flexible.
- In Korea, he avoided seed oils but ate some sweet potato.
- Travel requires more planning, supermarket visits, and food preparation.
- Example: roasting a chicken in the morning and packing it in a cooler for theme parks.
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Sugar Cravings and Dopamine
- A viewer reported going full carnivore, losing cravings, and walking past bakery aisles without temptation.
- Paul describes his own past sugar addiction, including Froot Loops, soft drinks, and up to six sugars in coffee.
- Stabilizing blood sugar reduces hunger and hangry episodes.
- Dopamine synthesis requires B12, iron, zinc, and low inflammation.
- Improved nutrient status raises baseline dopamine and reduces cravings.
- Ketones provide alternative brain fuel and improve energy.
- Better sleep and stable glucose reduce comfort eating.
- Leptin sensitivity improves when insulin is fixed.
- Paul does not fast because he believes benefits mainly help those on poor diets.
- He notes therapeutic fasting research by Dr. Matt Phillips for cancer.
- Intense exercise may boost autophagy more effectively than fasting.
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MCT Oil
- MCT oil can boost ketones therapeutically.
- It may help conditions such as dementia by raising ketone levels.
- Paul cautions against coconut oil due to phytosterols.
- C8 or C10 MCT oil is preferred.
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Carbohydrates and Body Composition
- A viewer asked whether 30 to 50 grams of carbs would slow muscle gain or fat loss on a high-meat diet.
- Excess carbohydrates are converted to saturated fat via de novo lipogenesis.
- The body stores about 400 grams of glycogen in muscles and 100 grams in the liver.
- Glycogen stores deplete after 12 to 24 hours of fasting.
- Exercise depletes glycogen faster.
- Carbs consumed around training may refill glycogen without raising triglycerides.
- Paul recommends continuous glucose monitors to observe individual responses.
- A glucose spike that looks like something you would not want to sit on is probably excessive.
- Bodybuilders with more muscle can tolerate more carbs than sedentary elderly people.
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Phytonutrients and Herbal Medicine
- A viewer reported craving phytonutrients after going keto.
- Paul states phytonutrients have no known role in mammalian physiology.
- There is no recommended daily intake or deficiency syndrome for phytonutrients.
- Some plant chemicals may have pharmacological effects, which makes them drugs rather than nutrients.
- Polyphenols such as resveratrol show benefits in lab studies but not in humans.
- Herbal medicine can have utility as pharmacological agents.
- Examples: aspirin from willow bark, digoxin from foxglove, artemisinin, morphine from poppies.
- Oregano oil has antimicrobial properties.
- Berberine may lower cholesterol through antimicrobial effects.
- Nattokinase may act as a biofilm disruptor.
- Plant substances used as drugs require awareness of dosing and side effects.
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Boron Deficiency
- A viewer raised boron deficiency as an important issue.
- Boron is not classified as an essential nutrient, but Paul believes it should be.
- Benefits include bone metabolism, reduced arthritis pain, parathyroid hormone regulation, vitamin D metabolism, and steroid hormone health.
- Veterinarians and farmers recognize boron deficiency, such as hip problems in pigs.
- Boron is the second most common deficiency Paul identifies in his patients.
- High-rainfall areas leach boron from soil, affecting crops and animals raised there.
- Testing is not covered by Medicare and is rarely done.
- Common use cases for supplementation include low testosterone, osteoporosis, and osteoarthritis pain.
- Dosing should be precise rather than a pinch.
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Protein and Kidney Health
- A viewer claimed eating too much animal protein destroys kidneys.
- Paul says this common belief is unproven and likely false for healthy kidneys.
- High protein intake does not damage healthy kidneys.
- A landmark study restricting protein in kidney disease patients found no benefit.
- Higher protein intake is associated with lower risk of chronic kidney disease in observational studies.
- Advising protein restriction causes sarcopenia and malnutrition.
- Meat provides protein and most micronutrients.
- The myth arose from animal models showing hyperfiltration after high-protein meals, but this is an adaptation, not damage.
- Damaged kidneys leak protein into urine.
- Restricting protein reduces urinary protein simply by lowering circulating protein, but it does not improve kidney health.
- Paul does not restrict protein in kidney disease.
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Conclusion
- Allison and Paul end episode two.
- They encourage viewers to ask doctors for evidence and to seek informed consent. :::
