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Any tips on dealing with symbols for programming?
On my 34-40 key layouts I put all the symbols typically used together in programming on the same layer, including symbols that usually require Shift, along with all the numbers. This makes it comfortable to type whole formulas without leaving the symbol layer and without needing Shift. Important bigrams that I can type without switching layers in the middle include <= >= != += -= *= /= %= &= |= -> /* */ => := :) ;) . I also optimize the layer so that none of these are same-finger bigrams. Because = appears in so many bigrams, I found it convenient to map it on a thumb key.
I make sure all the mods are comfortable to use and in the same place on all my layers, either as bottom row mod-taps or on opposite side thumb keys or worst case as a oneshot mod. I don't need Shift on my symbol layer, so one less mod to worry about.
Probably my favourite feature for a programming key map is _ on a base layer thumb key. That makes typing snake_case_names a breeze.