Community Intro

This community is now back and open for posting! Thanks to the Lemmy.world admins for granting me the mod role here.

My current goal for this community is for it to serve as the main, central community branching out into smaller, more substance-specific communities. Currently, the network is small, including:

• c/weed - Cannabis Discussion
• c/psy - Psychedelic Discussion
• c/mdma - MDMA / Ecstasy Discussion
• c/drank - Alcohol Discussion
• c/opi - Opiate Discussion

I'm also open to suggestions for other communities, and in need of people to help moderate them. (Lemmy usually doesn't require much, if any, moderation, but I'd still like to have a team of people anyway.)

Rules

The most critical rule for this and all related communities is NO SOURCING. Asking where to buy any drugs, including unregulated drugs, even in a "hey hit me up in DM's" sort of way, could get us shut down or worse. This is the regular old clearnet internet, the mods here and the Lemmy.world admins still have to worry about the law. It's not a moral thing and it is prohibition bullshit, but it's the world we've got for now, so work with us there please.

Aside from that, just be as kind as you can be to the people who are kind to you, don't recommend that people do anything which is more dangerous than drug use already inherently is (ie dangerous doses or combos), and we'll be good. (Note that these topics can still be discussed, people just shouldn't be encouraged to participate in behaviors which could cause them harm.)

Also, minors are not permitted to use c/Drugs or any of our networked communities. I don't think there are too many minors on Lemmy, but doesn't hurt to clarify that anyway.

Welcome again to c/Drugs!

Concept Credit

The concept and structure for the network of drug-related communities comes from my experience on 420chan over a decade ago (I am old). For those unfamiliar with 420chan, it was nothing like 4chan. It was the old internet, so it still had its problems (ie racism, which obviously won't be permitted here). But for example, it had a dedicated (supportive) transgender board and issued permanent bans to people who posted loli content. By old-internet-anonymous-imageboard standards, it wasn't the worst place to hang out.

It was also an important place for a weird young person like I was at the time, who wanted to know more about aspects of the world which were presented as taboo, but also wanted to know what was genuinely unsafe.

So thank you to Kirtaner and the mod team for all those fun years. When Kirt gets out of prison (for allegedly hacking the Texas Republican Party), if he wants me to stop using the old 420chan icons, just let me know. I just figured I'd do this because there are no plans to revive the original site and it serves an important function I think.

NeuralCIM is a version of erythropoietin (EPO) that only acts in the brain to increase a critical factor called BDNF, brain-Derived Neurological factor. BDNF promotes neo neurogenesis, new neurons to replace dying neurons in human brain. EPO is a very successful drug to promote red blood cell growth, but scientists knew the brain was full of EPO receptors, which have nothing to do with blood generation. If you give a patient too much EPO, their blood will dangerously thicken. See doping scandals in pro cycling early 2000s. But this version of EPO is taken through the nose right into brain, proven effective, just ask any cocaine addict.

The ATHENEA trial in 2023 concluded there was strong benefits of this drug in early-med Alzheimer, without severe adverse events. This is holding true since the trial, reported in 2025. This is in contrast to two US FDA approved Alzheimer drugs, Adumanucab and Leqembi, both of which have a high risk of inducing brain bleeding and death. Adumanucab has already been discontinued. Leqembi is US$400,000 a year per patient. The actual efficacy of Leqembi is "controversial". The cost of NeuralCIM: $25 for 10 doses. It is delivered intranasally.

So where are the media good news stories, why can't the world get this drug? Surely, at least one prominent American could use this drug.

The trick is in the name, CIM: Centro de Immuniologica Molecular. This is a Cuban research institute that famously developed a potent meningitis vaccine before anyone else. US Tourists are travelling to Cuba to buy this drug, prompted by US neurologists.

The caveat for ATHENEA was only 60 people in each test group, which established statistical significance over 4 years of trial, but the drug is now in the real world in Cuba and and we can expect large number data in a few more years.

It's a ironic that a treatment for Alzheimer is available only on an island under siege since 2025. We won't even go into why Adumanucab and leqembi were ever approved. BDNF is important for many neurological diseases.

cross-posted from: https://lemmy.world/post/50504433

Hi, my Dr. just started me on 10mg of Vyvanse, but I couldn't even feel it, so I tried taking 20mg yesterday morning, and I really felt that it made me more focused, slowed my mind down from racing thoughts, and made me more motivated. But I'm going back to 10mg today and talking to my Dr. about moving me up to 20mg on Thursday. What do you all think about Vyvanse?

My Dr. first started me on 15mg of Adderall XR, and I could not handle that. It came on too strong, lasted too long, made me clench my jaw all day, and made me jittery and nervous. Also, my Dr. has me on 0.5mg of Klonopin twice a day, but it's not really doing anything either. Back about 3 years ago, when I lived in another state, my psych Dr. had me on 2mg of Klonopin three times a day, and that did help.

But besides my ADHD, my real problem is anxiety and agoraphobia. I told my Dr. that sometimes I would take one of my mother's 2mg Xanax if I ever had to do anything in public or had an anxious situation. I told her I took one on our first appointment and that I was so nervous I almost cancelled our appointment 10 times leading up to it.

I also just sent my Dr. an email asking her if I could increase the Vyvanse to 20mg and the Klonopin to 1mg, but I have not heard back yet. I see her again Thursday, so maybe I shouldn't have sent her an email. I hate that I might be coming off weird, like I'm wanting more drugs, but that ain't it. I honestly can't even feel I've taken the dose.

But what do you all think about this, and what do you think about Vyvanse? BTW, this is the first time I've used Lemmy, first post ever on Lemmy, too, so please be easy on me lol. Thanks!

cocaine

bipolar in a powder

cross-posted from: https://lemmy.world/post/46674861

Greetings friends, and welcome to c/mdma!

This community has been shutdown / closed to new posts for 3 years for unclear reasons. It's now open to the public again!

c/mdma is now part of the c/drugs network of communities. c/drugs serves as the central Hub, branching off into more substance-specific discussions from there.

This also includes the establishment of some basic rules for this community:

Rules

(These rules apply across all communities in the c/Drugs network.)

No Sourcing - Do not request sources of any drugs at any time. This includes unregulated research chemicals. Any attempts, including "hit me up in DMs" type of requests, will result in a ban. This rule is necessary to keep this community open.

Harm Reduction - Do not recommend inherently dangerous doses or combinations of substances, or otherwise encourage behavior more risky than drug use already is by default. Clear attempts at causing intentional harm will result in a ban.

Avoid Dangerous Recommendations - Avoid recommending substances that have a reasonable chance of causing considerable harm to the user. For example, DPH, inhalants, or opioids. This rule is necessary to conform with Lemmy.World's Terms of Service. Posts violating this rule will be removed.

No Minors - Users under 18 years old are not permitted to use this community.

☺c/MDMA Rules☺

• Keep It Friendly - Be kind to your fellow humans. Disagreements, even impassioned ones, are fine. If you bring it down to the level of personal insults or excessive hostility, your posts may be removed. You may be banned in especially severe instances such as racism, sexism, Nazism, Zionism, etc.

It’s universally known that Kim Jong-un produces and distributes various substances and I could imagine that he also consumes.

While watching a documentary about North Korea, I imagined him having a really bad comedown on whatever he took and deciding “fuck it, scorched earth”, pressing the red button in a state of mania and sending nukes across the globe, resulting in an all out war against global forces, a one man army (and his military state), a captain sinking with his ship.

I should go to sleep, it’s 5am. :D

Horses getting personal again with a pretty wild story.

[P]lant scientists Paula Berman and Janka Höfer and their team set out to map and rebuild the biochemical pathways behind these compounds.

They identified the key genes used by two plants – Psychotria viridis and Acacia acuminata – to make DMT, and the step-by-step chemical pathways involved in producing the compound.

Then, they combined these with genes and pathways already known from psychedelic mushrooms (Psilocybe cubensis) and the cane toad (Rhinella marina), added supporting enzymes from rice and cress, then genetically introduced the combined genetic toolkit and kaboodle into tobacco plants (Nicotiana benthamiana).

The tobacco was chosen not because of its own drug production, but because it's basically the lab rat of plant species, with its fast growth.

Finally, the team carefully monitored the plant's production of five psychedelic tryptamines: DMT originally from plants; psilocin and psilocybin from mushrooms; and bufotenin and 5-MeO-DMT from toads.

The modified tobacco plants were found to produce all five compounds simultaneously. Because the different production pathways compete for the same resources, some compounds were produced in lower quantities than in their original sources.

However, the production was high enough to suggest that with a bit more tweaking, the system could function as a biological tryptamine factory for researchers.

I’m confused about caffeine pills.

Vivarin (200 mg), pic related and as of recent drug of choice works way better for me than off brand tablets. Feels like ~8 hours of energy. Then a big crash.

Tried many off-brand caffeine tablets, even double dose. Mostly just headaches though and not the same “clean” alertness.

I assumed quality control or additives or what not. But it’s literally just caffeine, right? Do other people see this? Could tablet fillers / how fast it dissolves matter? Or is this just tolerance + timing + placebo?

What’s the actual mechanism here?

Vivarin is the first time I understand why some people call it poor people's meth...

cross-posted from: https://lemmy.world/post/43854594

A “No-Veg” method flips plants straight to 12/12, trading smaller individual yields for higher annual output and a dramatic jump in top-shelf buds.

Abstract

This study revisits the hypothesis that Claviceps purpurea (Fr.) Tul., a fungus infecting cereals and producing ergot alkaloids (EAs), was the psychedelic agent in kykeon, the sacred elixir of the Eleusinian Mysteries. Although archaeological evidence supports this link, experimental data confirming the transformation of toxic ergopeptides into psychoactive lysergic acid amide derivatives in putative ancient preparations remain limited. The potential hydrolysis products of ergot were investigated using a technique that could have been readily applied by the priestesses of Eleusis, notably reacting in lye. Pulverized sclerotia were refluxed in solutions of lye and in distilled water. Samples obtained after liquid-liquid extractions were analyzed with 1H-NMR and UHPLC/Q-TOF-HRMS. The 1H NMR spectra demonstrated conversion of toxic ergopeptides, present in control samples but absent at all reaction times in 5% w/v ergot treated with pH 12.5 lye, where characteristic peaks for lysergic acid amide (LSA; ergine) and isolysergic acid amide (iso-LSA; isoergine; erginine) appeared. UHPLC/Q-TOF-HRMS quantitation confirmed this conversion, yielding 0.54 mg LSA and 0.48 mg iso-LSA per gram of ergot at 120 min. The chemical transformation of toxic EAs to psychoactive compounds, utilizing ancient technology, was demonstrated and supports the “psychedelic Eleusis” hypothesis.

cross-posted from: https://leminal.space/post/31736049

cross-posted from: https://lemmy.world/post/42316499

Psilocybin was the most popular, followed (surprisingly) by Amanita muscaria, then MDMA, then LSD.

That means 3.7% of the American population has microdosed. If you ask me, we have to up those numbers, and those dosages... it's not a bad start, but I'm worried that it's a way to cheapen the psychedelic experience, lending it to "enhancing productivity" instead of rewiring your psyche and breaking down social constructs.

If it helps people, it can't be a bad thing. I just hope it doesn't stop at "micro" for most people.

What do you all think?

I like doing coke sometimes, but it can be a bothersome process to pour from a baggie, cut it up, and needing to roll some paper or have a straw. Especially if you're out.

It's there a quicker or more convenient method? I've heard of tiny bottles with 1 hit doses, nasal sprays, even pressurized solutions.

What do you recommend? This could of course extend to other substances as well.

Recently I had COVID and as I powered through my headaches, I started to realize I was feeling a familiar smell - one that I had associated with being high on psychedelics.

As I thought about it, I realized more and more that it was the exact same smell, one that was deep in my trip memories. It isn't an unpleasant smell, just unique. And then I started thinking that COVID could be affecting similar parts of the brain as psychedelics and triggering a similar phantosmia (smell hallucinations).

I am wondering if this is something anyone else has noticed or was it just my own brain? Any comments?