I use a few different ones... Azander I have setup as a Healer, Isobel as a Tank, Sharp as "stuck in" DPS, and Ember as Ranged DPS. Ember is my favorite though. I think she has great voice lines. I think for me it is a tie between Ember and Sharp for the best story.

I never use one, so I can't really say I have a favorite. Lizard guy probably the best for the fishing buff alone though!