Hypothetically, if a colleague has repeatedly demonstrated the utter lack of reading comprehension skills (like pulling the same door labelled "push" for the hundredth time), what job could one suggest for them where this "disability" wouldn't be detrimental?

AFAIK it all boils down to the fact that during embryonal development our cells, which at that point were just a blob of undifferentiated autonomous chemical machines, somehow managed to unanimously agree upon the cardinal directions (up-down, left-right, front-back) for future development - and thanks to this, we don't have toes growing out of our ears.