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nottheonion·Not The OnionbyCMahaff

Fish Buttholes May Be The Reason We Now Have Fingers, Study Finds

cross-posted from: https://lemmy.world/post/36298939

New research reveals that the DNA switches controlling human finger development originated from genes that regulated fish cloacas 380 million years ago1.

"Rather than building a new regulatory system for the digits, nature has repurposed an existing mechanism, initially active in the cloaca," explains developmental geneticist Denis Duboule from the University of Geneva1.

The research team discovered this by comparing fish and mouse genomes, focusing on Hoxd genes. When they tagged DNA switches with fluorescent markers, these lit up in mouse digits but in fish cloacas. Deleting these genetic elements using CRISPR-Cas9 disrupted finger development in mice and cloaca formation in fish1.

"The common feature between the cloaca and the digits is that they represent terminal parts," notes geneticist Aurélie Hintermann. "Sometimes they are the end of tubes in the digestive system, sometimes the end of feet and hands"1.

Footnotes

  1. ScienceAlert - Fish Buttholes May Be The Reason We Now Have Fingers, Study Finds ↩ ↩2 ↩3 ↩4

Fish Buttholes May Be The Reason We Now Have Fingers, Study Findshttps://www.sciencealert.com/fish-buttholes-may-be-the-reason-we-now-have-fingers-study-findsOpen linkView original on lemmy.world
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keeptrack·Keep TrackbyCMahaff

Executive Order: STRENGTHENING AND UNLEASHING AMERICA’S LAW ENFORCEMENT TO PURSUE CRIMINALS AND PROTECT INNOCENT CITIZENS

This executive order potentially bolsters the police with military personnel and assets (illegally, for what that's worth), and IMO directs local police against their state representatives / citizens.

Executive Order: STRENGTHENING AND UNLEASHING AMERICA’S LAW ENFORCEMENT TO PURSUE CRIMINALS AND PROTECT INNOCENT CITIZENShttps://www.whitehouse.gov/presidential-actions/2025/04/strengthening-and-unleashing-americas-law-enforcement-to-pursue-criminals-and-protect-innocent-citizens/Open linkView original on lemmy.world
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keeptrack·Keep TrackbyCMahaff

01/30/2025 - F.C.C. Chair Orders Investigation Into NPR and PBS Sponsorships

Seth Stern, the director of advocacy at Freedom of the Press Foundation, said he believed Mr. Carr seemed to be setting up a legal pretext for interfering with public media.

“The end of Mr. Carr’s letter tellingly goes far beyond underwriting and talks about his thoughts on whether public media should be funded at all and notes that this underwriting issue might be relevant to a broader legislative debate,” Mr. Stern said. “That was troubling to read.”

01/30/2025 - F.C.C. Chair Orders Investigation Into NPR and PBS Sponsorshipshttps://www.nytimes.com/2025/01/30/business/media/npr-pbs-fcc-investigation.html?unlocked_article_code=1.tE4.ywhj.JfVK_GSEI1NVOpen linkView original on lemmy.world
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lemmydev·Lemmy App Development byCMahaff

FYI for Rust Developers, lemmy_api_common is no longer published to crates.io (0.18.3 and above)

You will want to change your Cargo.toml to point to the Lemmy Github repository + either a specific tag or branch for the version you want to target.

See the examples here: https://doc.rust-lang.org/cargo/reference/specifying-dependencies.html#specifying-dependencies-from-git-repositories

FYI for Rust Developers, lemmy_api_common is no longer published to crates.io (0.18.3 and above)https://github.com/LemmyNet/lemmy/commit/5cd4c6c5868c8bec964b6065d079f3a057885be7Open linkView original on lemmy.world
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bestoflemmy·BestOfLemmybyCMahaff

A list of casual communities on Lemmy (that aren't just tech news & politics)

cross-posted from: https://lemmy.world/post/2216085

Search Lemmyverse is good for finding communities.

I posted this on the other site but I thought I'd copy over here too, lots of good communities around to subscribe to if you want a more casual/fun frontpage that isn't just tech news, elon musk, or politics.

note: all of these communities have posts. If they appear empty, it simply means nobody on the instance you use has visited them before (or you might have blocked them and forgot, I've done it before, lol)!

Conversation communities

These are places that are 'chatty', good if you want a lot of comments.

"ask" based
Casual chat / Misc

Hobbies, Creative, & Passions

Misc
Artwork
Cooking, food, drinks

Generally mostly nice pics of food:

Gardening / Plants
Keyboard enthusiasts
Knitting, Stitching, Crocheting, etc
Reading & Writing
Sport

Honestly there are so many sport communities around - if you search Lemmyverse for popular sports, you will almost certainly find more.

Nice/Interesting/Funny pictures

Animals

Literally just pictures of cute animals.

Comics
Flags
Maps
Memes

Meme communities in general can overload your feed, so keep that in mind.

Photography

Games

Board Games / Table top games

The ttrpg.network instance has a lot of communities based around table top gaming & RPGs.

note: the battlemaps communities seem to mostly cross-post between eachother at the moment.

Video Games

Knowledge (e.g history, science)

Space

TV (television), movies, film

Music

Lots of music communities on Lemmy. Search Lemmyverse for genres of interest for more, this definitely isn't exhaustive.

Note that music communities generally have low comment counts, from my experience.

There's also:

View original on lemmy.world
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youshouldknow·You Should KnowbyCMahaff

YSK there are options for backing up / migrating your Lemmy subscriptions, blocks, etc.

(Full disclosure: I made one of the tools)

cross-posted from: https://lemmy.ca/post/1292268

lemmy.world cross-post link: https://lemmy.world/post/1251192

With the vlemmy situation ongoing, i feel like it would be useful to put this here (i did not make either of these tools)

Lemmy Account Settings Instance Migrator (LASIM) copies all your subscribed communities and blocks and lets you upload them to another account, in just a few clicks

lemmy-migrate does the same thing but without a GUI and support for uploading your backup to multiple accounts at once

View original on lemmy.world
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lemmy_support·Lemmy SupportbyCMahaff

When your instance defederates from another instance, their content can’t be pushed to you, but is there a way to stop your content from being pushed to them? (Answered: Misunderstanding)

Or have I misunderstood?

I suspect the response will be that content on your instance should always be considered public, and that you can't really stop a bad actor from spinning up fake instances or scraping your site for the data regardless, but I just wanted to confirm.

View original on lemmy.world
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plugins·Lemmy Plugins and UserscriptsbyCMahaff

LASIM - A little tool for migrating Lemmy settings / subscriptions / blocks between accounts

cross-posted from: https://lemmy.world/post/1060796

See the linked page for information about how it works, limitations, etc. and I'll of course answer any questions below!

As I have stated in the release section, this software is alpha so please don't be afraid to report bugs!

Releases are here: https://github.com/CMahaff/lasim/releases

Right now the program only supports Lemmy BE 0.18.1-rc9, but new releases will try to support new versions as they are released. The Lemmy API is changing a ton right now, but I'll try to keep up.

Note: Supports 0.18.1-rc9+ - I have tested it with rc9, rc10, and the final release of 0.18.1.

https://github.com/CMahaff/lasimOpen linkView original on lemmy.world
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general·General DiscussionbyCMahaff

I made a little tool for migrating Lemmy settings / subscriptions / blocks between accounts

See the linked page for information about how it works, limitations, etc. and I'll of course answer any questions below!

As I have stated in the release section, this software is alpha so please don't be afraid to report bugs!

Releases are here: https://github.com/CMahaff/lasim/releases

Right now the program only supports Lemmy BE 0.18.1-rc9, but new releases will try to support new versions as they are released. The Lemmy API is changing a ton right now, but I'll try to keep up.

https://github.com/CMahaff/lasimOpen linkView original on lemmy.world
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lemmy_support·Lemmy SupportbyCMahaff

Question About Lemmy API Versions

I'm working on a little tool for Lemmy using the rust backend (lemmy_api_common crate 0.17.4).

I've tested it against some 0.17.4 instances with no issues, but yesterday I went to test it more thoroughly on the official testing instances and had JSON parsing issues. I realized later that these servers are currently running 0.18.X.

Is this a bug? Or are we expecting that even within the "v3" APIs that you'll have breaking changes between Lemmy versions?

View original on lemmy.world
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nottheonion·Not The OnionbyCMahaff

The only manned submersible that could reach the missing Titan is owned by Steam's Gabe Newell

https://wegotthiscovered.com/news/the-only-manned-submersible-that-could-reach-the-missing-titan-is-owned-by-steams-gabe-newell/#:~:text=Home%20%2F%20gaming-,The%20only%20manned%20submersible%20that%20could%20reach%20the%20missing,owned%20by%20Steam's%20Gabe%20Newell&text=The%20world%20is%20nervously%20awaiting,the%20wreck%20of%20the%20Titanic.Open linkView original on lemmy.world
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