I was taking CDP-Choline for years based on recommendations from reddit nootropics at the time. And when I read eggs were a great source for them, I started consuming 2 eggs a day on top of that. I started pruning back some of my supplements as I wasn't sure they were helping. Choline was one of them, including eggs, and I didn't notice any reduction in my cognition.

Then about a year and a half ago, I forgot the reason, I ordered Alpha-GPC along with other supplements I would buy. After a month or so I felt a noticeable difference. I was sharper. Recalls were better. Learning also improved. I am still taking it to this day. My dose is 300mg of it daily, though bottle says I should take 600mg per day. I am taking half dose just out of caution and to observe moderation.

(personal note: I am a middle-aged male with concussion history who takes nootropics to enhance my brain health.)

the study: https://www.neurology.org/doi/10.1212/WN9.0000000000000057

Scientists at the University of Queensland partnered with researchers from the University of Minnesota to examine levels of adenosine triphosphate (ATP) - known as the "energy currency" molecule - in the brains and blood cells of young people with depression.

cross-posted from: https://piefed.social/c/science/p/1708790/alzheimer-s-fully-reversed-in-mice-scientists-say

In our latest attempts to make lab rats immortal, a new compound has been shown to reverse late stage Alzheimer's disease in lab mice. This is a rare case where the title isn't even clickbait.

cross-posted from: https://lemmy.today/post/44911953

In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

Researchers have synthesized enhanced vitamin K analogues that outperform natural vitamin K in promoting neuron growth. The new compounds, which combine vitamin K with retinoic acid, activate the mGluR1 receptor to drive neurogenesis. They also efficiently cross the blood-brain barrier and show stability in vivo.

Archive article: https://archive.ph/fWqbL

TLDR: Middle-aged rats who were given varying doses of β-hydroxy β-methylbutyrate (HMB), a metabolite of the essential amino acid leucine showed improvements in memory.

However the doses are ridiculously high IMO: 225 (low), 450 (medium), and 900 (high) mg/kg body weight/day.

cross-posted from: https://lemmy.world/post/32461703

cross-posted from: https://rss.ponder.cat/post/221468

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