Duloxetine works great for me until I sleep, then I wake back up into the pit of despair and I feel like I’m supposed to wait until ~24 hours since I last took it in order to take it again. I can’t find any cases of other people reporting this and it’s not something my medical professionals have heard of. It makes it hard if I don’t have energy due to not getting enough sleep the night before so I take a nap, and then when I wake up I still don’t have energy due to lack of willpower. I’ve also found it harder to get out of bed in the morning shortly before taking the medicine.