Rick & Morty may not translate directly into live action well, but here's a show to scratch some of that itch perhaps; "Counterpart".

There's no comedy, but like the edginess and inner conflict Rick has. That is sort of what I get from this, a little.

Pretty good imdb rating. I'm 8 episodes in, I like it. JK Simmons could definitely pull off a Rick. One of the more serious ones at least.