I think it's completely enjoyable without knowing anything about Hololive. The only thing you would be missing out on is the memes that the weapons and items are based on.
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HoloCure - Update 0.6 Trailer (HoloLive ID members + HoloHouse farming sim mode, out August 17) | Spyke
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The game is entirely free too.
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Personally have avoided the hololive/vtuber rabbit hole, but heard good things about this game and figured I'd post about the update.
I think it's completely enjoyable without knowing anything about Hololive. The only thing you would be missing out on is the memes that the weapons and items are based on.