Yikes. That’s why I get a little worried about the high velocity neck stuff that some chiropractors do.

At least in the first study, they did an analysis of the non-pharm funded studies and saw some good results. Unfortunately that’s pretty much the best we can go off of.

Sure, this one probably comes closest to what you’re looking for. Looks like modest benefit. Nothing super effective but enough to make a positive difference generally. I definitely recognize that they can have side effects, so decisions should be personalized.

https://onlinelibrary.wiley.com/doi/10.1111/acps.13541

There are some other older ones done before 2022 as well like this one.

https://psychiatryonline.org/doi/10.1176/appi.focus.16407

SSRIs seem to work better than placebo on average