San Francisco 49ers at Seattle Seahawks
Lumen Field, Seattle WA
Odds: Line: SEA -7, Over/Under: 44.5
Discuss whatever you wish. You can trash talk, but keep it civil.
San Francisco 49ers at Philadelphia Eagles
Lincoln Financial Fieldm Philadelphia, PA
Odds: Line: PHI -6 Over/Under: 44.5
Discuss whatever you wish. You can trash talk, but keep it civil.
Seattle Seahawks at San Francisco 49ers
Levi's Stadium, Santa Clara, CA
Odds: Line: SEA -2.5 Over/Under: 47.5
Discuss whatever you wish. You can trash talk, but keep it civil.
Chicago Bears at San Francisco 49ers
Levi's Stadium, Santa Clara, CA
Odds: Line: SF -3.5 Over/Under: 51.5
Discuss whatever you wish. You can trash talk, but keep it civil.
San Francisco 49ers at Indianapolis Colts
Lucas Oil Stadium, Indianapolis, Indiana
Odds: Line: SF -4.5 Over/Under: 46.5
Discuss whatever you wish. You can trash talk, but keep it civil.
Tennessee Titans at San Francisco 49ers
Levi's Stadium, Santa Clara, CA
Odds: Line: SF -12.5 Over/Under: 44.5
Discuss whatever you wish. You can trash talk, but keep it civil.
San Francisco 49ers at Cleveland Browns
Huntington Bank Field, Cleveland, OH
Odds: Line: SF -5.5 Over/Under: 35.5
Discuss whatever you wish. You can trash talk, but keep it civil.
Carolina Panthers at San Francisco 49ers
Levi's Stadium, Santa Clara, CA
Odds: Line: SF -7 Over/Under: 49.5
Discuss whatever you wish. You can trash talk, but keep it civil.
San Francisco 49ers at Arizona Cardinals
State Farm Stadium, Glendale, AZ
Odds: Line: SF -3.5 Over/Under: 48.5
Discuss whatever you wish. You can trash talk, but keep it civil.
LA Rams at San Francisco 49ers
Levi’s Stadium, Santa Clara, CA
Odds: Line: LAR -5.5 Over/Under: 49.5
Discuss whatever you wish. You can trash talk, but keep it civil.
San Francisco 49ers at New York Giants
MetLife Stadium, East Rutherford, NJ
Odds: Line: SF -2.5, Over/Under: 47.5
Discuss whatever you wish. You can trash talk, but keep it civil.
San Francisco 49ers at Houston Texans
NRG Stadium, Houston, TX
Odds: Line: HOU -3.5, Over/Under: 41.5
Discuss whatever you wish. You can trash talk, but keep it civil.
Atlanta Falcons at San Francisco 49ers
5:20 PM, October 19, 2025
Levis Stadium, Santa Clara CA
Odds: Line: SF -1.5 Over/Under: 46.5
Discuss whatever you wish. You can trash talk, but keep it civil.
San Francisco 49ers at Tampa Bay Buccaneers
Raymond James Stadium, Tampa, FL
Odds: Line: TB -3.5, Over/Under: 46.5
Discuss whatever you wish. You can trash talk, but keep it civil.
San Francisco 49ers at Los Angeles Rams
SoFi Stadium, Inglewood, CA
Odds: Line: LAR -8.5, Over/Under: 43.5
Discuss whatever you wish. You can trash talk, but keep it civil.
Jacksonville Jaguars at San Francisco 49ers
Levis Stadium, Santa Clara CA
Odds: Line: SF -3.5 Over/Under: 45.5
Discuss whatever you wish. You can trash talk, but keep it civil.
Arizona Cardinals at San Francisco 49ers
Levis Stadium, Santa Clara CA
Odds: Line: SF -1.5 Over/Under: 44.5
Discuss whatever you wish. You can trash talk, but keep it civil.
San Francisco 49ers at Seattle Seahawks
Lumen Field, Seattle WA
Odds: Line: SF -1.5, Over/Under: 43.5
Discuss whatever you wish. You can trash talk, but keep it civil.
Los Angeles Chargers at San Francisco 49ers
Levis Stadium, Santa Clara CA
Odds: Line: LAC -2.5 Over/Under: 35.5
Discuss whatever you wish. You can trash talk, but keep it civil.
