Just want to share my experience in regard to installing Fedora Kinoite for non-technical folks. I have had Fedora Kinoite installed on different machines with different hardware since Fedora 36.

Every single time I want to upgrade to another major version (say 36 -> 37) something goes wrong, and I have to manually dig through the notes and issues to fix them via the command line. The problem has been unique every time I have wanted to upgrade; either the repos have issues or there's a dependency problem while upgrading or a host of other problems that hinder major upgrades via a single click through the GUI frontend. I had Kinoite installed for non-technical people because it seemed to be the perfect option for having a rock solid system that's hard to break. But after having to intervene EVERY single time they had to upgrade to a major version, I am convinced that I need to consider another distro for my use case.

Also, a huge thanks to the contributors and the developers of the ostree variants of Fedora such as Silverblue and Kionete.

Is anybody using distrobox on NixOS to develop and run software? What are your thoughts on using it?

I feel like it's a huge time saver and makes the use of NixOS easier for beginners. Instead of spending an afternoon or a few days trying to compile or run something using nix, you can spin up a box and seamlessly do your development there. This makes prototyping and testing things out way easier before investing a bunch of time trying to nixify it.