This study describes the identification of an antibiotic class acting via LpxH, involved in lipopolysaccharide synthesis having potent in vivo efficacy against bloodstream infections caused by the critical Gram-negative pathogens E. coli and Klebsiella pneumoniae. Further development of this class of antibiotics could make an important contribution to the ongoing struggle against antibiotic resistance.

https://www.pnas.org/doi/10.1073/pnas.2317274121 (open access)

This study attempts to identify the “protective” genetic factors that can modify or reduce the effect of APOEε4 on Alzheimer’s disease risk and to identify new pathogenic mechanisms, proteins, and pathways that inform development of therapeutic targets and diagnostics.

https://link.springer.com/article/10.1007/s00401-024-02721-1 (open access).

Brief anger can temporarily impair blood vessel function, potentially heightening heart disease and stroke risks, finds new study in the Journal of the American Heart Association.

The newly discovered letter, written by a German Jesuit to Pope Pius XII’s personal secretary, suggests that the pope knew of Hitler’s atrocities but chose to remain silent.

The nations are taking bold steps in the espionage shadow war to try to collect intelligence on leadership thinking and military capabilities.

Feline thief Gingee, a four-year-old Maine Coon, has been ransacking nearby homes in Buckley, Flintshire.

The most startling moment for owners Jay Phoenix, 43 and Mathew Westlake-Toms, 31, was when Gingee delivered a stolen knife to their bedroom at night.