Taking direct inspiration from Lilith Fair, the inaugural event features a lineup of only female artists or female-fronted bands, including Chappell Roan, Bikini Kill, Doechii, Mitski, the Breeders, Garbage, Katseye, Santigold, and Rachel Chinouriri. The day will also include rising acts Not for Radio, Die Spitz, Quiet Light, and Eli, and special guests Stevie Nicks, Karen O, and Sarah McLachlan.

Net profits from ticket sales are directed toward nonprofit organizations dedicated to advancing and advocating for women and girls, such as the Center for Reproductive Rights, Planned Parenthood, and Johns Hopkins Center for Indigenous Health. All of the artists have agreed not to take a profit from their performances.