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The crux of this seems to be

The first of these patterns was characterized by a reduced communication between brain regions (i.e., hypoconnectivity), while the other entailed an increased communication between brain regions (i.e., hyperconnectivity).

"Importantly, these patterns did not simply entail 'more' or 'less' connectivity everywhere, but organized brain-wide patterns that could be linked to distinct biology," said Gozzi.

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The team's observations could improve the neuroscientific understanding of autism. If they are validated in further studies, they could eventually also inform the development of new support tools and practices that account for differences between individual patients.

"Two individuals may both receive an autism diagnosis, and may even show overlapping behavioral features, but the brain and molecular mechanisms contributing to their condition could be quite different," said Gozzi.

"That distinction matters if we want to move toward more precise and personalized interventions. I would emphasize that this is not yet a clinical diagnostic tool. However, it provides a framework for future precision psychiatry in autism.

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Autism may have two distinct subtypes based on brain connectivity patterns | Spyke