"Let's face it, this is not the worst thing you've caught me doing." - Tony Stark, 'Iron Man'.
"The right information at the right time is deadlier than any weapon." - Martin Collins, 'Westworld', Season 3 Episode 5.
"Nobody normal ever accomplished anything meaningful in this world." - Jonathan Byres, 'Stranger Things', Season 2 Episode 1.
"It was like having a whole weather system turn against me. Just hate message after hate message, around the clock, all piling on. It’s hard to describe what that does to your head. Suddenly there’s a million invisible people, all talking about how they despise you. It’s like a mental illness." - Tess, 'Black Mirror', Season 3 Episode 6.
By Grabthar's Hammer, you shall be avenged!
"By Grabthar's Hammer, What a savings!"
I've seen things you people wouldn't believe.
"I swear by my pretty floral bonnet, I will end you."
"Curse your sudden but inevitable betrayal."
"I'll be in my bunk".
"The SPECIAL hell!"
.... I could continue but basically anything from firefly.
Firefly came so fast to my head I forgot to add
"So say we all"
"Smoke me a kipper, I'll be back for breakfast!"
Other honorable mentions
What does God need with a starship?
“I am that guy”