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[DNA macroarray analysis of gene expression changes in rat brain after single administration of 2-aminoadamantane compound][Article in Russian]

This is a study of the nootropic drug Bromantane, showing long lasting epigenetic changes after a single dose. Although there is no evidence the drug has a similar effect in humans, the anecdata in /r/nootopics and /r/nootropics tends to report long lasting effects even after discontinuation of the drug. There are many reports saying things like "this is the best ADHD drug I've ever tried", etc, suggesting the obvious conspiracy theory that sub-par drugs are prescribed because they are patented and profitable, compared to this Soviet drug from the 80s.

[DNA macroarray analysis of gene expression changes in rat brain after single administration of 2-aminoadamantane compound][Article in Russian]https://pubmed.ncbi.nlm.nih.gov/15856951/Open linkView original on lemmy.world
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rhino_hornbill
lemmy.world

However, because of the poorly understood mechanism and long time scale it operates on, most people that try Bromantane end up giving themselves insomnia, decide they don't like it, then give up. Also only the nasal spray ROA seems to be effective... https://www.reddit.com/r/NooTopics/comments/119454s/bromantane_experience_and_questions/

Personally I disliked Bromantane when I tried it for a month long cycle, but then I did another cycle with ALCAR included and I cannot express enough how great this drug is. I just started a third cycle because the effects have started to wear off.

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[DNA macroarray analysis of gene expression changes in rat brain after single administration of 2-aminoadamantane compound][Article in Russian] | Spyke