Alzheimer’s Breakthrough: Researchers Discover Novel Way To Potentially Halt Disease Progression
This study focuses on the manipulation of the plexin-B1 protein to enhance the brain’s ability to clear amyloid plaques in Alzheimer’s disease, opening avenues for future therapeutic strategies to potentially halt the progression of the disease
https://scitechdaily.com/alzheimers-breakthrough-researchers-discover-novel-way-to-potentially-halt-disease-progression/Open linkView original on literature.cafe
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I'm surprised. As I understand it, the Alzheimer's field is starting to recognize that the plaques are likely a result of, rather than a cause of, the disease. And that the cause may be more related to a, potentially microglia related, inflammatory problem in the CNS
There are sort of two paths in the research. Some are following the Amyloid Plaque route still. There was a bit of kerfuffle with some of the evidence in other studies which was the basis of this route: https://www.science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease
Once you're too far down one path of research, you pretty much can't stop, or you risk your entire career, evidence be damned.
Thanks, that was a good read. It is terrible that some researchers end up committing such scientific fraud. Although I am inclined to blame the involved researchers themselves, ultimately, I believe that inflexible (and insufficient) funding is the real culprit
No, there was plenty of money. It was narcissistic assholes trying to prove they earned a Nobel Prize.
It's was the enshitification of US science and pharma. Mainly led by fraud, and very poor models of disease in mice. This paper is not different.
I suspect both methods will be necessary. Step A - clean up amyloid. Step B stop excess amyloid production.