For League matches during the 2021/22 season, Clubs were able to field three substitutes from seven nominated, which has now increased following Friday's Annual General Meeting (AGM) when EFL Clubs approved a number of regulation changes that will come into effect immediately.

Each Club is only permitted a maximum of three opportunities to make substitutions during the fixture, plus an opportunity at half-time, and a Club may make more than the one substitution at each of these opportunities.